A bottle of Intravenous infusion set may be pierced to ensure easy flow. The presence of this hole leads to a dash of air to the inside of the package and may continue to leak air into the blood vessels that merge with blood after entry of the amount of solution. It leads to the formation of air bubbles and blood clots within those vessels leading to obstruction of vessels transporting blood to vital areas of the body turn off the spigot and the blood supply to these areas Voted vital