Leukemia the bone marrow and other blood-forming organs produce increased numbers of certain type of white blood cells. The study found extracts of Leea indica showed high cytotoxicity on K562 human leukemia cell and IC 50 values of fractions F4 is 59ug. Apoptotic morphological changes in K562-60 cells induced by Leea indica. Thus strongly believed that Leea indica contain biological active compounds against the leukemia cells as a potent therapeutic agent for treatment leukemia patients