Acne vulgaris is a common skin condition affecting 9.4% of the global population, driving demand for safe and natural anti-acne products. A key factor that aggravates acne inflammation is the colonization of Staphylococcus aureus, which damages the skin barrier and triggers inflammatory responses. Kombucha, a fermented tea product, produces postbiotic compounds with antibacterial and anti-inflammatory properties, yet the potential of Kombucha Ferment Filtrate (KFF) in topical formulations for ac