Pibet-Smile is an innovative product made from natural betel leaves. This innovation was developed as a substitute for traditional candy to prevent tooth decay. The active compounds such Flavonoid found in Piper betel can inhibit the growth of bacteria that cause tooth decay. This study used three formulations with concentrations of F1 1%, F2 2.5%, and F3 5%. Organoleptic tests of Pibet-Smile showed F3 to be the best choice.