Termites, known scientifically as Isoptera, cause countless damage worldwide, such as damaging construction buildings which causes more than US$ 50 billion. Azadirachtin in Neem Seed oil contains insecticide effects, especially to termites. Black Pepper Essential Oil contains the properties of antioxidant which is a great candidate of this termiticide. The effect of N.O.B.P.E.O will be on Macrotermes Gilvus, ensuring that worker termites spread toxicity of N.O.B.P.E.O to the entire colony